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The Use of Pharmacological-challenge fMRI in Pre-clinical Research
 

The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System

Article DOI: 10.3791/3956-v • 11:28 min • April 25th, 2012
April 25th, 2012 •
1, 2, 1, 2, 1
1Department of Radiology, Brain Imaging Center, Academic Medical Center Amsterdam, 2Biological Imaging Centre, MRC Clinical Sciences Centre, Imperial College London

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요약
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The goal of this technique is to assess serotonin (5-HT) neurotransmitter function in the live and free-breathing animal with pharmacological magnetic resonance imaging (phMRI) and an intravenous challenge with a selective serotonin reuptake inhibitor (SSRI), fluoxetine.

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Pharmacological-challenge FMRI Pre-clinical Research 5-HT System Neurobiological Mechanisms Drug Action Neurotransmitter-related Disorders Depression ADHD Imaging Methods PET SPECT CT Brain Disorders Neuronal Connectivity Clinical Investigations Molecular Imaging Strategies Spatial Resolution Contrast-agent Radio-labeled Molecules Ionizing Radiations Functional MRI Psycho-motor Task Adaptation Of FMRI Specific Neurotransmitter System Serotonin (5-HT) Physiological Conditions Pathological Conditions
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