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Chapters
- 00:05Title
- 01:30Animal Preparation and Cold Treatment
- 02:18Injection of FDG
- 04:01Micro-PET/CT Imaging
- 07:29Post-imaging Analysis
- 08:54Results: FDG Uptake in Mouse BAT
- 10:06Conclusion
A method of functional imaging of mouse brown adipose tissue (BAT) is described in which cold-stimulated uptake of 18F-Fluorodeoxyglucose (FDG) in BAT is non-invasively assessed with a standardized micro-PET/CT protocol. This method is robust and sensitive to detect differences in BAT activities in mouse models.
Tags
Functional ImagingBrown FatMice18F-FDG Micro-PET/CTEnergy ExpenditureThermogenesisSympathetic Nervous SystemAdrenergic ReceptorBody Mass Index (BMI)Diabetic ParametersAnti-obesity/anti-diabetes TherapyEnergy BalanceCold Challenge-based Positron Emission Tomography (PET)Standardized ProtocolSmall Animal ModelsC57BL/6J MiceFasting Conditions18F-Fluorodeoxyglucose (FDG)Micro-PET/CT SystemPET ImagesCT Images
