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Met behulp van de BLT Gehumaniseerd Muis als een Stem Cell gebaseerde Gene Therapy tumormodel
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1Department of Medicine, Division of Hematology-Oncology,David Geffen School of Medicine at UCLA, 2UCLA AIDS Institute, 3Eli & Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA, 4Department of Medical and Molecular Pharmacology,David Geffen School of Medicine at UCLA, 5Department of Microbiology, Immunology and Molecular Genetics,David Geffen School of Medicine at UCLA
Chapters
- 00:05Title
- 01:26Tissue Transplantation
- 05:27Results: PET Imaging Is a More Sensitive and Accurate Way to Assess Tumor Regression and Clearance
- 06:41Conclusion
Het genereren en karakteriseren van tumorspecifieke T-cellen met gehumaniseerde muizen wordt hier beschreven. Human thymusweefsel en genetisch gemodificeerde humane hematopoietische stamcellen worden getransplanteerd in immunodeficiënte muizen. Dit resulteert in de bereiding van een op menselijke immuunsysteem waardoor in vivo onderzoek van anti-tumor immuunrespons.
Tags
BLT Humanized MouseStem Cell-based Gene TherapyTumor ModelSmall Animal ModelsMiceHuman DiseaseTherapeutic InterventionsMouse ImmunityViral DiseasesHuman Immunodeficiency Virus (HIV) InfectionHumanized Mouse ModelsC. B 17 Scid/scid MiceHuman Fetal ThymusFetal LiverThy/liv (SCID-hu)Adoptive Transfer Of Human Peripheral Blood Leukocytes (SCID-huPBL)Physiologically Relevant ModelBLT Stands For Bone Marrow/liver/thymusNOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) Immunocompromised MiceHuman Hematopoietic Stem Cell TransplantHIV Infection And Latency
