JoVE 비디오를 활용하시려면 도서관을 통한 기관 구독이 필요합니다. 전체 비디오를 보시려면 로그인하거나 무료 트라이얼을 시작하세요.
Chapters
- 00:00Title
- 01:28Overall Scheme of the Experiment
- 02:36Preparation of Pathogenic Antibody
- 04:06Injection of Collagen VII-specific IgG into Mice
- 06:47Clinical Evaluation of Disease Severity
- 09:13Analysis of Tissue-bound and Circulation Collagen-specific Antibodies
- 10:19Representative Results
- 11:41Conclusions
Im Tiermodell in unserem vorliegenden Arbeit beschriebenen gereinigten IgG-Antikörpern gegen eine Strecke von 200 Aminosäuren (aa 757-967) von Kollagen VII werden wiederholt in Mäuse Wiedergeben der Blasenbildung Phänotyp sowie der Histo-und immunpathologischen charakteristischen Merkmale der menschlichen eingespritzt Epidermolysis bullosa acquisita (EBA)<sup> 1</sup>.
Tags
Granulocyte-dependentAutoantibody-inducedSkin BlisteringAutoimmune PhenomenaSelf-toleranceAutoimmune ResponseWitebsky’s PostulatesDiagnosing Autoimmune DiseasePassive Transfer Of AutoantibodiesEpidermolysis Bullosa Acquisita (EBA)Experimental ModelsCollagen VIIBlistering PhenotypeHisto- And Immunopathological FeaturesHuman EBAWidespread DiseaseDose Of Administered Collagen VII-specific IgGGranulocyte Recruitment And ActivationInflammatory Pathway
