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Chapters
- 00:05Title
- 01:14Cell Preparation
- 02:43Surgery Preparation
- 03:54Surgical Access to Thyroid and Cell Injection
- 04:44Post-operative Care and Tissue Collection
- 05:30Results: Histological Verification of Anaplastic Thyroid Carcinoma
- 06:35Conclusion
Generation of an orthotopic mouse model of anaplastic thyroid carcinoma is described here. This technique employs surgical placement of human anaplastic thyroid cancer cells into the thyroid of immunodeficient mice, thus creating a more clinically relevant setting to study disease progression as well as screen innovative therapeutic interventions.
