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Behavior

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JoVE Journal Behavior
Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET
 

Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking

Article DOI: 10.3791/50358-v • 14:21 min • August 6th, 2013
August 6th, 2013 •
1,2,3,4, 1,3, 1,3,4, 3,4, 5, 6, 1,2,3
1Diagnostic Radiology, Yale University, 2Psychiatry, Yale University, 3Yale PET Center, Yale University, 4Biomedical Engineering, Yale University, 5Nuclear Medicine, Massachusetts General Hospital, 6Radiological Sciences, University of California, Irvine

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요약
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We present a novel PET imaging approach for capturing dopamine fluctuations induced by cigarette smoking. Subjects smoke in the PET scanner. Dynamic PET images are modeled voxel-by-voxel in time by lp-ntPET, which includes a time-varying dopamine term. The results are 'movies' of dopamine fluctuations in the striatum during smoking.

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Keywords: Dynamic PET Dopamine Fluctuations Cigarette Smoking Lp-ntPET Time-varying Parameters HYPR Spatial Filter Statistical Comparison Voxel-level Modeling Dopamine Movie
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