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5/6th联合切除术，高盐饮食和一氧化氮合酶抑制剂诱导Lewis大鼠慢性肾脏病

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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

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5/6th联合切除术，高盐饮食和一氧化氮合酶抑制剂诱导Lewis大鼠慢性肾脏病

DOI:

10.3791/50398-v

•

08:50 min

•

July 03, 2013

•

Arianne van Koppen, Marianne C. Verhaar, Lennart G. Bongartz, Jaap A. Joles

¹Department of Nephrology & Hypertension,University Medical Center Utrecht

Chapters

00:05Title
01:15Preparation for Surgery
05:13Left Side Subtotal Nephrectomy
06:12Representative Nephrectomy Results
08:23Conclusion

Summary

자동 번역

两阶段方法建立Lewis大鼠慢性肾脏病（CKD），通过手术取出肾质量5/6th描述。结合的外科手术过程中，一氧化氮合酶抑制和高盐饮食导致类似人类的CKD的模型，允许因果机制的研究和发展新的治疗干预。

Tags

Keywords: 5/6th Nephrectomy Chronic Kidney Disease Lewis Rat High Salt Diet Nitric Oxide Synthase Inhibition Glomerular Filtration Rate Renal Plasma Flow Hypertension Proteinuria Uremia Tubulo-interstitial Damage Glomerulosclerosis

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