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1Department of Pharmaceutical Sciences,University of Toronto, 2The Institute of Biomaterials and Biomedical Engineering,University of Toronto, 3Ontario Cancer Institute,Campbell Family Institute For Cancer Research and Techna Institute, 4Department of Biomedical Engineering,University at Buffalo, The State University of New York
Chapters
- 00:05Title
- 01:41Preparation of Porphysomes
- 05:27In vivo Photothermal Therapy
- 07:43Porphysome Characterization and Tumor Treatment Results
- 09:23Conclusion
Vi udviklede nye iboende multifunktionelle nanovesicles kaldet porphysomes, som har struktur-afhængige fluorescens selv-quenching og unikke photothermal egenskaber og fungerer dermed som potente photothermal terapi agenter. Vi formulerede porphysomes hjælp højtryk ekstrudering og undersøgte deres photothermal terapi effekt i en xenograft tumor model.
Tags
PorphysomesPhotothermal Tumor AblationIntrinsic Multifunctional NanovesiclesPhotosensitizerPyropheophorbide αPhospholipidLiposome-like Spherical VesiclesExtinction CoefficientsFluorescence Self-quenchingPhotothermal EfficacyHigh Pressure ExtrusionTumor Temperature IncreaseLaser IrradiationThermal AblationEscharsPhotothermal Therapy (PTT)
