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Cel dood in verband met abnormale Mitosis Waargenomen door confocale Imaging Live kankercellen
 
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Cel dood in verband met abnormale Mitosis Waargenomen door confocale Imaging Live kankercellen

Article DOI: 10.3791/50568-v • 15:53 min • August 21st, 2013
August 21st, 2013 •
1, 2,3, 4, 4, 5, 1,6, 2,3
1Cancer Research Center, Sheba Medical Center, 2The Neufeld Cardiac Research Institute, Tel-Aviv University, 3Department of Physiology and Pharmacology, Tel-Aviv University, 4Imaging Unit, Sackler Faculty of Medicine, Tel-Aviv University, 5Biotechnology and Cell Signaling, Ecole Superieure de Biotechnologie Strasbourg, 6Department of Human Molecular Genetics and Biochemistry, Tel-Aviv University

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De cytotoxische activiteit van de fenanthridine PJ-34 in kankercellen ondergaan mitose werd in real time gedocumenteerd door levende confocale beeldvorming. PJ-34 uitgeroeide menselijke borstkanker MDA-MB-231 cellen die extra-centrosomes in mitose. In tegenstelling tot normale bifocale mitose, werden de extra-centrosomes niet geclusterd in de twee polen spil in aanwezigheid van PJ-34.

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Kankerbiologie Geneeskunde Cellular Biology Moleculaire Biologie Biomedische Technologie Anatomie Fysiologie genetica Neoplastic Processen farmacologische acties Live confocale beeldvorming Extra-centrosomes clustering / de-clustering Mitotische Catastrophe celdood PJ-34 myocardiaal infarct microscopie imaging
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