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1The Markey Cancer Center,University of Kentucky College of Medicine, 2Graduate Center for Toxicology,University of Kentucky College of Medicine, 3Department of Molecular and Biomedical Pharmacology,University of Kentucky College of Medicine, 4Department of Pediatrics,University of Kentucky College of Medicine
Chapters
- 00:05Title
- 02:12Preparation of C57Bl/6 K14-Scf Mice and Topical Forskolin Treatment
- 04:31Reflective Colorimetry and Calculating the Minimal Erythematous Dose
- 08:15Representative Melanin Induction Results
- 11:43Conclusion
Epidermal Melanin wird durch die topische Anwendung von Forskolin in einem murinen Modell der hellhäutigen UV-empfindliche Menschen verursachte. Pharmakologische Manipulation von cAMP-Konzentrationen in der Haut und Epidermis stark verdunkelt Schutz gegen UV-vermittelte Entzündungen (Sonnenbrand), wie durch die minimale erythematöse Dosis (MED)-Assay gemessen.
