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Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism
 

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Article DOI: 10.3791/50840-v • 12:38 min • December 18th, 2013
December 18th, 2013 •
1, 1, 1, 1, 1, 1
1Department of Life Sciences, National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev

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요약
Automatic Translation

To study the relationship between protein homeostasis, stress and aging, we monitored changes in protein folding by following protein dysfunction, protein localization in the cell and protein stability at the organismal, cellular and protein levels, using the genetically tractable metazoan Caenorhabditis elegans as a model system.

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Keywords: Protein Homeostasis Proteostasis Caenorhabditis Elegans Protein Folding Protein Function Protein Misfolding Metastable Proteins Behavioral Assays Imaging Biochemical Approaches Temperature-sensing Development Aging Metabolism
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