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Chapters
- 00:05Title
- 01:20Monitoring Behavior by Thermo-resistance
- 02:35Monitoring Protein Localization by Immunostaining
- 07:39Monitoring Protein Folding and Stability by Partial Digestion
- 09:46Monitoring Protein Folding and Stability in a Multicellular Organism
- 12:11Conclucion
To study the relationship between protein homeostasis, stress and aging, we monitored changes in protein folding by following protein dysfunction, protein localization in the cell and protein stability at the organismal, cellular and protein levels, using the genetically tractable metazoan Caenorhabditis elegans as a model system.
