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浸润性膀胱移行细胞癌中的完整的人MUC1转基因小鼠免疫诱导免疫治疗发展模型

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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

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浸润性膀胱移行细胞癌中的完整的人MUC1转基因小鼠免疫诱导免疫治疗发展模型

DOI:

10.3791/50868-v

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11:02 min

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October 30, 2013

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Daniel P. Vang, Gregory T. Wurz, Stephen M. Griffey, Chiao-Jung Kao, Audrey M. Gutierrez, Gregory K. Hanson, Michael Wolf, Michael W. DeGregorio

¹Department of Internal Medicine, Division of Hematology and Oncology,University of California, Davis, ²Comparative Pathology Laboratory, UC Davis School of Veterinary Medicine,University of California, Davis, ³Merck Serono Research,Merck KGaA, Darmstadt, Germany

Chapters

00:05Title
01:43Bladder Cancer Induction and Vaccination Treatments
02:49Monitoring and Sample Collection
04:11Multiplex Fluorometric Microbead Immunoassay
06:37IFN-γ/IL-4 ELISpot Preparation and Analysis
08:07Representative Transitional Cell Bladder Carcinoma Induction Results
10:39Conclusion

Summary

자동 번역

的N-丁基-N-（4 - 羟丁基）亚硝胺的人粘蛋白1（MUC1）测试的目的MUC1基因定向免疫治疗的转基因小鼠中诱导的膀胱癌模型的开发。施用MUC1的目标肽疫苗后，MUC1的细胞毒性T淋巴细胞反应证实，通过测定血清中的细胞因子水平和T细胞的比活性。

Tags

Bladder Cancer Transitional Cell Carcinoma Squamous Cell Carcinoma MUC1 Transgenic N-butyl-N-(4-hydroxybutyl)nitrosamine Cytokines Immunotherapy Peptide Vaccine T-cell Response

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