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Induktion av invasiva Transitional Cell blåskarcinom i immuna intakt human MUC1 transgena möss
 
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Induktion av invasiva Transitional Cell blåskarcinom i immuna intakt human MUC1 transgena möss: En modell för immunterapi utveckling

Article DOI: 10.3791/50868-v • 11:02 min • October 30th, 2013
October 30th, 2013 •
1, 1, 2, 1, 1, 1, 3, 1
1Department of Internal Medicine, Division of Hematology and Oncology, University of California, Davis, 2Comparative Pathology Laboratory, UC Davis School of Veterinary Medicine, University of California, Davis, 3Merck Serono Research, Merck KGaA, Darmstadt, Germany

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En N-butyl-N-(4-hydroxibutyl) nitrosamin-inducerad blåscancer modell utvecklades i human mucin 1 (MUC1) transgena möss för att testa MUC1-riktad immunterapi. Efter administrering av en MUC1-riktad peptidvaccin, var en cytotoxisk T lymfocytsvaret MUC1 bekräftades genom mätning av serum cytokinnivåer och T-cell specifik aktivitet.

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Medicin urinblåsa djur genetiskt modifierade cancervaccin immunterapi djurförsöksnämnden Modeller neoplasier blåscancer C57BL / 6 mus MUC1 immunterapi preklinisk modell
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