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Chapters
- 00:00Title
- 00:06Introduction
- 02:30Pre-Operative Care and Anesthesia
- 02:43Preparation of the Surgical Site
- 03:22Tracheal Intubation in Rat
- 04:05Constriction of Ascending Aorta
- 07:05Post-operative Care
- 07:58Confirmation of Successful Constriction of Ascending Aorta
- 08:14Representative Results
- 09:21Conclusion
We describe a stepwise procedure for creating pressure overload and left ventricular hypertrophy in Wistar rats by constriction of the ascending aorta using a small metallic clip. This model is extensively used for studying remodeling changes during cardiac hypertrophy and for identifying and evaluating strategies for regression of such changes.
