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1Department of Anesthesiology and Critical Care,Perelman School of Medicine, University of Pennsylvania, 2Department of Pharmacology,Perelman School of Medicine, University of Pennsylvania, 3Department of Neuroscience,Perelman School of Medicine, University of Pennsylvania, 4Center for Sleep and Circadian Neurobiology,Perelman School of Medicine, University of Pennsylvania
Chapters
- 00:05Title
- 01:13Test Apparatus Set-up
- 02:55System Checking and Calibration
- 03:50Temperature Transponder Implantation
- 04:22Animal Habituation
- 05:02Step-wise Testing os Anesthetic Sensitivity
- 06:35Time to Emergence Testing
- 07:37Results: Effect of Ibotenic Acid on Anesthetic Sensitivity
- 08:26Conclusion
Loss of the righting reflex has long served as a standard behavioral surrogate for unconsciousness, also called hypnosis, in laboratory animals. Alterations in volatile anesthetic sensitivity caused by pharmacological interventions can be detected with a carefully controlled high-throughput assessment system, which may be adapted for delivery of any inhaled therapeutic.
