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Bioengineering

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Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor
 

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor

Article DOI: 10.3791/51102-v 11:17 min February 10th, 2014
February 10th, 2014

챕터

요약

The Organic Electrochemical Transistor is integrated with live cells and used to monitor ion flux across the gastrointestinal epithelial barrier. In this study, an increase in ion flux, related to disruption of tight junctions, induced by the presence of the calcium chelator EGTA (ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetra acetic acid), is measured.

Tags

Keywords: Organic Electrochemical Transistor Barrier Tissue Disruption Gastrointestinal Tract EGTA Paracellular Flux Transepithelial Resistance Drug Discovery Pathogen/toxin Diagnostics High-throughput Screening
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