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면역학 및 감염병학

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鼠标型号病原体引起的慢性炎症局部及全身站点

JoVE 신문
면역학 및 감염병학

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JoVE 신문 면역학 및 감염병학

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

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鼠标型号病原体引起的慢性炎症局部及全身站点

DOI:

10.3791/51556-v

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09:52 min

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August 08, 2014

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George Papadopoulos*¹, Carolyn D. Kramer*¹, Connie S. Slocum, Ellen O. Weinberg, Ning Hua, Cynthia V. Gudino, James A. Hamilton, Caroline A. Genco

¹Department of Medicine, Section of Infectious Disease,Boston University School of Medicine, ²Department of Biophysics,Boston University School of Medicine

Chapters

00:05Title
01:55Growth and Cultivation of Bacteria
03:25MRI Data Acquisition
05:00Aorta Pinning
06:07Lipid Staining and Lesion Quantification
07:27Results: Pathogen-induced Chronic Inflammation at Local and Systemic Sites
08:52Conclusion

Summary

자동 번역

动物模型中已被证明是在界定有助于慢性炎症的发展宿主和病原体的具体机制的宝贵工具。在这里，我们描述口腔感染的小鼠模型与人类病原体牙龈卟啉和细节的方法，以评估炎症的进展，在局部和全身的部位。

Tags

Mouse Model Chronic Inflammation Pathogen-induced Porphyromonas Gingivalis Periodontal Disease Atherosclerosis Inflammatory Response Alveolar Bone Vascular Endothelium Inflammatory Mediators Transgenic Mice Bacterial Mutants Therapeutic Strategies

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