Journal
/
화학
/
酰胺偶联反应为双吡啶基配体及其络合合成，以白金为双核抗癌药物
JoVE 신문
화학
JoVE 비디오를 활용하시려면 도서관을 통한 기관 구독이 필요합니다.  전체 비디오를 보시려면 로그인하거나 무료 트라이얼을 시작하세요.
JoVE 신문 화학
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Please note that all translations are automatically generated. Click here for the English version.

酰胺偶联反应为双吡啶基配体及其络合合成，以白金为双核抗癌药物

DOI:
10.3791/51740-v

•

07:20 min

•

May 28, 2014

•

, , , ,
1Faculty of Pharmacy,The University of Sydney, 2School of Science and Health,University of Western Sydney, 3Division of Chemistry and Environmental Science, School of Science and the Environment,Manchester Metropolitan University, 4Nature Publishing Group

Chapters

  • 00:05Title
  • 01:22Synthesis of the N,N’-(alkane-1,n-diyl)diisonicotinamide
  • 02:32Purification of the Ligands
  • 03:23Synthesis and Purification of the Dinuclear Platinum Complexes
  • 05:09Results: Characterization of Bispyridine Ligands and Dinuclear Platinum Complexes
  • 06:54Conclusion

Summary

자동 번역

자동 번역

这个协议描述了使用异烟酸和二氨基​​烷烃的酰胺偶联反应，以形成适合于在多核铂配合物，其中结合的抗癌药物BBR3464和吡铂方面的合成中使用的桥接配体。

Tags

Amide CouplingBispyridine LigandsPlatinum Anticancer AgentsDinuclear Complexes1H NMRIsonicotinic AcidDiaminoalkaneTriethylamine1-propylphosphonic AnhydrideTransplatinMultinuclear ComplexesHydrogen Bonding

Article

Embed

플레이리스트에 추가

Usage Statistics

Related Videos

抗癌金属配合物的合成与细胞毒性评价MTT法

分裂和池合成及肽叔酰胺图书馆表征

非均匀掺Pr的SrTiO的合成<sub> 3</sub>陶瓷及其热电性能

纳米尺寸钛酸二氢钠的合成和化学反应

科大-1作为香兰素的合成的非均相催化剂

蛋白质生物缀合物的合成<em>通过</em>半胱氨酸马来酰亚胺化学

环状聚合物的合成及其在熔融状态扩散运动的表征在单分子水平

制备及<em>体外</em>磁共振成像基于树状大分子造影剂的表征

铂镍纳米线的合成及减氧性能优化

稳定笼 Aziridinium 离子的制备及其开环 Azaheterocycles 的合成

Read Article