JoVE 비디오를 활용하시려면 도서관을 통한 기관 구독이 필요합니다. 전체 비디오를 보시려면 로그인하거나 무료 트라이얼을 시작하세요.
Chapters
- 00:05Title
- 01:16Coverslip Preparation
- 02:37Globoid Cell Induction in Mixed Glial Cultures
- 04:30Analysis and Characterization of Globoid Cells in Primary Culture
- 06:12Results: Representative Microglial Cells After Psychosine and Latex Bead Phagocytosis
- 07:15Conclusion
Globoid cells are a defining pathological feature of Krabbe disease, a leukodystrophy currently lacking an effective long-term therapy. We have developed a cell culture model to study the innate biology and pathogenic potential of activated microglia and their transformation into globoid cells.
