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原发性肿瘤和/或转移相关的临床前和治疗的临床开发的离体处理响应
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Ex Vivo Treatment Response of Primary Tumors and/or Associated Metastases for Preclinical and Clinical Development of Therapeutics
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原发性肿瘤和/或转移相关的临床前和治疗的临床开发的离体处理响应

DOI:
10.3791/52157-v

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08:29 min

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October 02, 2014

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, , , , , , ,
1Department of Pathology,Memorial Sloan Kettering Cancer Center, 2Molecular Pharmacology and Chemistry Program,Memorial Sloan Kettering Cancer Center, 3Department of Radiology,Weill Cornell Medical College, 4Department of Medicine,Memorial Sloan Kettering Cancer Center, 5Department of Oncology,Memorial Sloan Kettering Cancer Center, 6Department of Surgery,Memorial Sloan Kettering Cancer Center

Chapters

  • 00:05Title
  • 02:30Tissue Procurement
  • 04:09Preparation of Materials for Sectioning and Vibratome Settings
  • 05:19Tissue Sectioning, Treatment, and Analyses
  • 06:25Results: Ex Vivo Metastatic Breast Cancer Response to Heat Shock Protein 90 Inhibitor
  • 07:56Conclusion

Summary

자동 번역

자동 번역

建立癌症细胞系和裸鼠已经癌症研究的中流砥柱，在过去的几十年。然而，最近的证据表明，治疗响应在很大程度上是通过肿瘤细胞微环境的影响。因此，我们开发了原发肿瘤标本进行药物开发目的的体外分析。

Tags

Ex Vivo Tumor ModelPrimary Tumor SamplesTumor MicroenvironmentTreatment ResponsePreclinical Drug DevelopmentClinical TherapeuticsCancer Cell LinesTumor XenograftsTumor-microenvironment Crosstalk

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