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Chapters
- 00:05Title
- 02:06Monitoring the Estrous Cycle
- 03:25Pre-exposure and Habituation/Fear Conditioning
- 05:41Estradiol Preparation and Administration, Extinction Training, and Extinction Recall
- 07:05Results: Extinction of Conditioned Fear in Naturally Cycling Female Rats
- 08:27Conclusion
Gonadal hormones such as estrogen modulate memory formation in a number of experimental paradigms including fear extinction memory. This protocol describes a set of methods for investigating the influence of gonadal hormones specifically during extinction in naturally cycling females, including estrous cycle monitoring and exogenous estrogen administration.
