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Immunology and Infection
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JoVE Journal Immunology and Infection
Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes
 

Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes

Article DOI: 10.3791/52381-v • 10:11 min • September 27th, 2014
September 27th, 2014 •
1, 1, 2, 1
1Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 2Research Technology Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health

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Work with infectious Ebola viruses is restricted to biosafety level 4 laboratories. Tetracistronic minigenome-containing replication and transcription-competent virus like particles (trVLPs) represent a lifecycle modeling system that allows us to safely model multiple infectious cycles under biosafety level 2 conditions, relying exclusively on Ebola virus components.

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Keywords: Ebola Virus Virus-like Particles Tetracistronic Minigenomes Biosafety Level 2 Virus Lifecycle Modeling Replication And Transcription-competent Virus-like Particles VP40 GP1,2 VP24 Morphogenesis Budding Entry Genome Replication Transcription
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