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Experimental Glaucoma Induced by Ocular Injection of Magnetic Microspheres
 

Experimental Glaucoma Induced by Ocular Injection of Magnetic Microspheres

Article DOI: 10.3791/52400-v • 06:35 min • February 2nd, 2015
February 2nd, 2015 •
1, 1, 2, 2,3, 2,4, 5, 1,6, 1
1Ocular Biology and Therapeutics, University College London Institute of Ophthalmology, 2University College London Institue of Ophthalmology, 3Moorfields Eye Hospital, 4NIHR Biomedical Research Centre, Moorfields Eye Hospital, 5Schepens Eye Research Institute, Harvard Medical School, 6Hoffman-La Roche

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요약
Automatic Translation

We present a method for inducing elevated intraocular pressure (IOP), by injecting magnetic microspheres into the rat eye, to model glaucoma. This leads to strong pressure rises, and extensive neuronal death. This protocol is easy to perform, does not require repeat injections, and produces stable long-lasting IOP rises.

Tags

Glaucoma Animal Models Experimental Glaucoma Ocular Injection Magnetic Microspheres Intraocular Pressure Iridocorneal Angle Fluid Outflow Trabecular Meshwork Neuronal Death Ganglion Cell Layer Optic Nerve Pathology Rat Eye Model
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