Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Padmavathy Nandha Premnath; Sandra Craig; Campbell McInnes

doi:10.3791/52441

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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

DOI:

10.3791/52441-v

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10:33 min

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October 26, 2015

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Padmavathy Nandha Premnath, Sandra Craig, Campbell McInnes

¹Department of Drug Discovery and Biomedical Sciences,University of South Carolina

Chapters

00:05Title
01:57Computational Identification of Potential Small Molecule Capping Groups
04:03Synthesis of Potential N-capping Groups
06:25Solid Phase Synthesis for the Generation of FLIPs
08:45Results: Identification of More Drug-like Inhibitors of CDK2 through the Cyclin Groove
09:59Conclusion

Summary

자동 번역

We describe implementation of the REPLACE strategy for targeting protein-protein interactions. REPLACE is an iterative strategy involving synthetic and computational approaches for the conversion of optimized peptidic inhibitors into drug like molecules.

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

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Chapters

Summary

자동 번역

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