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Doku Dejenerasyonu / Yenilenme ve Kanser Araştırmaları Murin İndüklenebilir Telomeraz allelleri kullanılması
JoVE Journal
Medicine
This content is Free Access.
JoVE Journal Medicine
Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
DOI:

08:34 min

April 13, 2015

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Chapters

  • 00:05Title
  • 01:35Reactivation of Telomerase in mTERT-ER and LSL-mTERT Mice In Vivo
  • 02:33Isolation of Neural Stem Cells and Reactivation of Telomerase In Vitro
  • 05:07Telomere FISH
  • 06:37Results: Effect of Telomerase Reactivation
  • 08:01Conclusion

Summary

Automatic Translation

Telomere and telomerase play essential roles in ageing and tumorigenesis. The goal of this protocol is to show how to generate two murine inducible telomerase knock-in alleles and how to utilize them in the studies of tissue degeneration/regeneration and cancer.

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