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Chapters
- 00:05Title
- 02:07Preparations of the Swine
- 02:27Preparatory Surgery
- 05:15Determining Baseline Refractory Period
- 05:46Determining Baseline AF Burden
- 06:34Pericardial Drug Delivery and Post-Treatment Time-points
- 06:55Heart Explantation
- 08:16Reanimation and In Vitro Study Paradigm
- 08:54Pericardial Administration of Docosahexaenoic Acid
- 09:23Conclusion
We have developed a swine model for the target delivery of pharmacological agents within the pericardial space/fluid. Using this approach, the relative benefits of administered agents on induced atrial fibrillation, relative refractory periods and/or ischemic protection can be investigated.
