Journal
/
/
ืขื™ืจื•ื™ stereotaxic ืฉืœ Oligomeric ืขืžื™ืœื•ืื™ื“-ื‘ื™ืชื ืœื”ื™ืคื•ืงืžืคื•ืก ื”ืขื›ื‘ืจ
JoVE ์‹ ๋ฌธ
์‹ ๊ฒฝ๊ณผํ•™
JoVE ๋น„๋””์˜ค๋ฅผ ํ™œ์šฉํ•˜์‹œ๋ ค๋ฉด ๋„์„œ๊ด€์„ ํ†ตํ•œ ๊ธฐ๊ด€ ๊ตฌ๋…์ด ํ•„์š”ํ•ฉ๋‹ˆ๋‹ค.  ์ „์ฒด ๋น„๋””์˜ค๋ฅผ ๋ณด์‹œ๋ ค๋ฉด ๋กœ๊ทธ์ธํ•˜๊ฑฐ๋‚˜ ๋ฌด๋ฃŒ ํŠธ๋ผ์ด์–ผ์„ ์‹œ์ž‘ํ•˜์„ธ์š”.
JoVE ์‹ ๋ฌธ ์‹ ๊ฒฝ๊ณผํ•™
Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus
DOI:

โ€ข

08:16 min

โ€ข

June 17, 2015

โ€ข

, , , ,

Chapters

  • 00:05Title
  • 01:18Animal Preparation
  • 02:16Surgery and Infusion
  • 05:40Animal Removal and Postoperative Care
  • 06:23Results: Oligomeric Aβ1-42 Induces Neuron Death in the Dentate Gyrus and the Basal Forebrain
  • 07:40Conclusion

Summary

์ž๋™ ๋ฒˆ์—ญ

Here, we present a protocol for direct stereotaxic brain infusion of amyloid-beta. This methodology provides an alternative in vivo mouse model to address the short-term effects of amyloid-beta on brain neurons.

Related Videos

Read Article