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Infusión estereotáxica de Oligomeric beta-amiloide en el hipocampo del ratón
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신경과학
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JoVE 신문 신경과학
Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus
DOI:

08:16 min

June 17, 2015

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Chapters

  • 00:05Title
  • 01:18Animal Preparation
  • 02:16Surgery and Infusion
  • 05:40Animal Removal and Postoperative Care
  • 06:23Results: Oligomeric Aβ1-42 Induces Neuron Death in the Dentate Gyrus and the Basal Forebrain
  • 07:40Conclusion

Summary

자동 번역

Here, we present a protocol for direct stereotaxic brain infusion of amyloid-beta. This methodology provides an alternative in vivo mouse model to address the short-term effects of amyloid-beta on brain neurons.

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