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Chapters
- 00:05Title
- 01:13Preparation of Cannula and Obturator
- 03:13Preparation of Microinjector
- 05:32Performing Microinjection
- 08:50Results: Reduced Rat Motivation to Self-administer Ethanol by Overexpressing DREADDs in Nucleus Accumbens Core Astrocytes
- 09:35Conclusion
Rodents are an appropriate model to investigate the molecular substrates of behavior and complex psychiatric disorders. Brain microinjection in awake rodents can be used to elucidate disease substrates. An efficient and customizable brain microinjection method as well as the execution of an operant paradigm that quantifies motivation is presented.
