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Chapters
- 00:05Title
- 02:10Surgical Preparation and Positioning
- 05:09Surgical Procedure
- 08:07Round Window Application of Ototoxic Agent
- 09:52Results: Targeted Cochlear Damage After Heptanol Exposure
- 11:18Conclusion
Various methods exist for introducing ototoxic agents to the cochleae of animal models. Presented is a surgical protocol for delivery of ototoxic agents to the round window niche. The procedure is reliable, creates targeted intra-cochlear lesions, and avoids mechanical damage to the microarchitecture. Examination of cochlear self-repair/regeneration is possible.
