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Chapters
- 00:05Title
- 01:12Abdominal Laparotomy
- 02:52Aneurysm Clip Placement
- 04:09Lipopolysaccharide (LPS) Amniotic Sac Injection
- 05:45Results: Representative Effects of Transient Systemic Hypoxia-ischemia (TSHI) + LPS in Embryonic Rats
- 07:00Conclusion
Encephalopathy of prematurity encompasses the central nervous system abnormalities associated with injury from preterm birth. This report describes a clinically relevant rat model of in utero transient systemic hypoxia-ischemia and intra-amniotic lipopolysaccharide administration (LPS) that mimics chorioamnionitis, and the related impact of infectious stimuli and placental underperfusion on CNS development.
