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Chapters
- 00:05Title
- 00:39Cochlea Dissection
- 03:15Post Immunohistochemistry Mounting and Imaging
- 04:39Results: Morphology and Immunofluorescence in Control and Cilia Mutant Cochlea
- 06:16Conclusion
Primary cilia influence various signaling pathways. The mammalian cochlea is ideal for examining planar cell polarity (PCP) signaling. Cilia dysfunction affects cochlear outgrowth, cellular patterning and hair cell orientation, readouts of PCP. Our goal is to analyze PCP signaling in mouse cochlea via phenotypic analysis, immunohistochemistry and scanning electron microscopy.
