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Inductie van Maternal Immune Activering in Muizen bij Mid-dracht Podium met Viral Mimic Poly (I: C)
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JoVE 신문 면역학 및 감염병학
Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)
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Inductie van Maternal Immune Activering in Muizen bij Mid-dracht Podium met Viral Mimic Poly (I: C)

DOI:
10.3791/53643-v

•

07:13 min

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March 25, 2016

•

, ,
1Division of Biology and Biological Engineering,California Institute of Technology, 2Harvard Medical School

Chapters

  • 00:05Title
  • 00:57Timed-mating Pair Setup
  • 02:23Poly(I:C) Injection
  • 03:55MIA Adult Offsrping Behavioral Abnormality Evaluation
  • 05:33Results: MIA Adult Offsrping Exhibit Abnormalities Associated with Autism and Schizophrenia
  • 06:42Conclusion

Summary

자동 번역

자동 번역

Maternal immune activation (MIA) is a model for an environmental risk factor of autism and schizophrenia. The goal of this article is to provide a step-by-step procedure of how to induce MIA in the pregnant mice in order to enhance the reproducibility of this model.

Tags

Maternal Immune ActivationMIAMiceViral Mimic Poly(I:C)Mid-gestation StageNeuro-immunologyBrain Development행동분석학Environmental Risk FactorAutismSchizophreniaInduction MethodTimed Mating PairEstrous Cycle SynchronizationEar Punch LabelingDark CycleBody Weight RecordingMale Mouse AdditionPlug Detection

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