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JoVE Journal Bioengineering
Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels
 

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Article DOI: 10.3791/53769-v • 10:10 min • August 15th, 2016
August 15th, 2016 •
*1, *1, 1, 1,2, 3, 4, 5, 1
1Department of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, 2Università degli studi e-Campus, 3ICRM, CNR - Consiglio Nazionale delle Ricerche, 4Elettra Sincrotrone Trieste, 5Department of Chemistry, University of Torino
* These authors contributed equally

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요약
Automatic Translation

The motion regimes of ibuprofen encapsulated in β-cyclodextrin nanosponges polymer network are investigated using pulsed-field-gradient spin-echo (PGSE) NMR technique. Synthesis, purification, drug loading, implementation of the NMR pulse sequence and data analysis to work out the mean square displacement of the drug at several observation times are described in detail.

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Keywords: Cyclodextrin Nanosponges Hydrogels Ibuprofen Transport Properties HR-MAS NMR Spectroscopy Drug Delivery Step-growth Polymerization EDTA Dianhydride
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