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Bioengineering

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JoVE Journal Bioengineering
A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds
 

A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds

Article DOI: 10.3791/53885-v • 13:34 min • April 6th, 2016
April 6th, 2016 •
*1, *1, *3, 1, 1,4, 2, 3, 1,4, 1
1Department of Tissue Engineering and Regenerative Medicine (TERM), University Hospital Wuerzburg, 2Department of Cardiothoracic Surgery, University Hospital Wuerzburg, 3Department of Bioinformatics, University Wuerzburg, 4Translational Center Wuerzburg, Fraunhofer Institute Interfacial Engineering and Biotechnology IGB
* These authors contributed equally

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요약
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We present a three-dimensional (3D) lung cancer model based on a biological collagen scaffold to study sensitivity towards non-small-cell-lung-cancer-(NSCLC)-targeted therapies. We demonstrate different read-out techniques to determine the proliferation index, apoptosis and epithelial-mesenchymal transition (EMT) status. Collected data are integrated into an in silico model for prediction of drug sensitivity.

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Keywords: 3D Tissue Engineering In Vitro In Silico Lung Tumor Model Drug Effectiveness Mutational Backgrounds Non-small Cell Lung Cancer Targeted Therapies Cell-specific Responses Pre-clinical Drug Testing Tumor Entities Drug Response Predictions Bioreactor Gefitinib ELISA Ki67 Staining
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