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Using Micro-computed Tomography for the Assessment of Tumor Development and Follow-up of Response to Treatment in a Mouse Model of Lung Cancer
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Using Micro-computed Tomography for the Assessment of Tumor Development and Follow-up of Response to Treatment in a Mouse Model of Lung Cancer

Using Micro-computed Tomography for the Assessment of Tumor Development and Follow-up of Response to Treatment in a Mouse Model of Lung Cancer

DOI:
10.3791/53904-v

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11:31 min

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May 20, 2016

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, , , , , ,
1Division of Pulmonary Medicine,Keio University School of Medicine, 2Department of Developmental Biology,Washington University School of Medicine

Chapters

  • 00:05Title
  • 00:58Micro-CT Imaging of Mice
  • 03:21Micro-CT Image Analysis
  • 05:03Experimental Treatment and Follow-up Scanning
  • 07:05Lung Collection
  • 08:33Results: Assessing Lung Tumor Formation and Inhibition using CT-Scans and Histological Confirmation
  • 10:15Conclusion

Summary

자동 번역

자동 번역

We describe a method for the detection of tumor nodule development in the lungs of an adenocarcinoma mouse model using micro-computed tomography and its use for monitoring changes in nodule size over time and in response to treatment. The accuracy of the assessment was confirmed with end-point histological quantification.

Tags

Keywords: Micro-CTTumor AssessmentLung CancerMouse ModelTumor DevelopmentTreatment ResponseReal-time MonitoringNon-invasive ImagingImage AnalysisAnesthesiaAnimal Handling

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