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Chapters
- 00:05Title
- 00:47Neonatal Hind Limb Test
- 02:31Weanling Observation Test
- 04:26Wire Mesh Grip Strength Test
- 06:15Tissue Staining: NADH Diaphorase or Succinate Dehydrogenase
- 07:47Results: HTRA2-/- Mice Testing and Histology
- 09:08Conclusion
A reverse-genetics approach to understanding gene families associated with human disease is presented, using mouse as a model system, and the subsequent mouse phenotyping schedule is described. Because mice defective in a gene of interest, HtrA2, manifested Parkinsonian symptoms, the phenotyping regimen is focused on identifying neurological defects.
