An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

00:05Title
01:09Synthesis of a Linear Peptoid
05:08Side-chain Deprotection and Cleavage from Resin
06:32Cytotoxicity Assay against Leishmania mexicana Axenic Amastigotes
09:12Results: Synthesis and Characterization of Peptoids and Their Cytotoxicity to Leishmania mexicana
10:33Conclusion

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A protocol to synthesize peptoids with mixed cationic functionality in the same sequence is presented (lysine- and arginine-type monomers). Subsequent testing of these compounds against Leishmania mexicana, the protozoan parasites that cause cutaneous leishmaniasis, is also described.

对于拟肽与他们抗利什曼原虫活性混合赖氨酸型/精氨酸型单体及评价合成的有效方法

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