Journal
/
의학
/
Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases
JoVE 신문
의학
JoVE 비디오를 활용하시려면 도서관을 통한 기관 구독이 필요합니다.  전체 비디오를 보시려면 로그인하거나 무료 트라이얼을 시작하세요.
JoVE 신문 의학
Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases

DOI:
10.3791/54796-v

•

07:47 min

•

December 06, 2016

•

, , , ,
1Inserm, U1191,Institute of Functional Genomics, 2CNRS,UMR-5203, 3Université de Montpellier

Chapters

  • 00:05Title
  • 01:04Pre-operative Preparation
  • 01:58Vasculature Labeling and Thinned Skull Window Preparation
  • 04:41Two-photon Microscopy
  • 06:12Results: Logitudinal In Vivo Imaging of the Cerebrovasculature
  • 07:10Conclusion

Summary

자동 번역

자동 번역

This manuscript describes a procedure to track the remodeling of the cerebrovasculature during amyloid plaque accumulation in vivo using longitudinal two-photon microscopy. A thinned-skull preparation enables the visualization of fluorescent dyes to assess the progression of cerebrovascular damage in a mouse model of Alzheimer's disease.

Tags

In Vivo ImagingCerebrovasculatureCNS Diseases신경과학Vascular RemodelingMinimally InvasivePial VesselsPenetrating Cortical VesselsBlood-brain BarrierFITC-dextranRetro-orbital InjectionHead Mount DeviceCyanoacrylic Glue

Article

Embed

플레이리스트에 추가

Usage Statistics

Related Videos

check_url/kr/54796?article_type=v

The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System
check_url/kr/54796?article_type=v

Intranasal Administration of CNS Therapeutics to Awake Mice
check_url/kr/54796?article_type=v

In vivo Macrophage Imaging Using MR Targeted Contrast Agent for Longitudinal Evaluation of Septic Arthritis
check_url/kr/54796?article_type=v

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
check_url/kr/54796?article_type=v

Transplantation into the Anterior Chamber of the Eye for Longitudinal, Non-invasive In vivo Imaging with Single-cell Resolution in Real-time
check_url/kr/54796?article_type=v

In vivo 19F MRI for Cell Tracking
check_url/kr/54796?article_type=v

Acute Brain Trauma in Mice Followed By Longitudinal Two-photon Imaging
check_url/kr/54796?article_type=v

In Vivo Imaging and Tracking of Technetium-99m Labeled Bone Marrow Mesenchymal Stem Cells in Equine Tendinopathy
check_url/kr/54796?article_type=v

Rose Bengal Photothrombosis by Confocal Optical Imaging In Vivo: A Model of Single Vessel Stroke
check_url/kr/54796?article_type=v

Depletion of Mouse Cells from Human Tumor Xenografts Significantly Improves Downstream Analysis of Target Cells

Read Article