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合成与阿司匹林富马酸酯前药的表征抑制NFκB活动和乳腺癌干细胞

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Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

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合成与阿司匹林富马酸酯前药的表征抑制NFκB活动和乳腺癌干细胞

DOI:

10.3791/54798-v

•

13:38 min

•

January 18, 2017

•

Irida Kastrati, Loruhama Delgado-Rivera, Gergana Georgieva, Gregory R. J. Thatcher, Jonna Frasor

¹Physiology and Biophysics, College of Medicine,University of Illinois at Chicago, ²Medicinal Chemistry and Pharmacognosy, College of Medicine,University of Illinois at Chicago, ³College of Pharmacy,University of Illinois at Chicago

Chapters

00:05Title
01:13Synthesis of Aspirin-fumarate Prodrug, GTCpFE
06:10Inhibiting the NFκB Activity with GTCpFE in Breast Cancer Cells
07:22Inhibiting Breast Cancer Stem Cells with GTCpFE In Vitro
10:11Results: GTCpFE Inhibits the NFκB Pathway, Mammosphere Formation, and the CD44⁺CD24^– Immunophenotype in Breast Cancer Cells
11:49Conclusion

Summary

자동 번역

This procedure will demonstrate how we synthesized and characterized the anti-NFκB and anti-cancer stem cell activity of an aspirin-fumarate prodrug.

Tags

Aspirin-fumarate Prodrug GTCpFE Anti-inflammatory NF-ÎºB Inhibition Breast Cancer Stem Cells Synthesis Characterization Anti-cancer Activity Repurposed Drugs Multidisciplinary Approach

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