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Два методы, чтобы создать Hypoparathyroid Мыши: паратиреоидэктомию Использование GFP железах и дифтерийно-Токсин-опосредованной паратиреоидного абляции
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Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
DOI:

07:13 min

March 14, 2017

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Chapters

  • 00:05Title
  • 01:18Parathyroidectomy Using GFP Glands
  • 04:08Diphtheria-Toxin-Mediated Parathyroid Ablation
  • 04:50Results: Phenotypes of 2 Acquired Hypoparathyroidism Mouse Models
  • 06:16Conclusion

Summary

자동 번역

Mice with acquired hypoparathyroidism would be useful for studying novel drug therapies for hypoparathyroidism. Two procedures to create such mice are demonstrated. The GFP-PTX mouse is generated by surgical parathyroidectomy guided by green fluorescing parathyroid glands. A second, non-surgical approach is based on parathyroid-specific expression of the diphtheria toxin receptor.

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