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Chapters
- 00:05Title
- 00:46Murine Dorsal Root Ganglion (DRG) Dissection
- 03:39Semisolid Matrix Droplets Preparation, DRG Insertion, and Head and Neck Cancer Cell Plating
- 06:44Results: Representative Neurite Outgrowth Analyses
- 08:07Conclusion
Perineural invasion (PNI) is a common feature of head and neck squamous cell carcinoma (HNSCC), conferring lower survival rates. Its mechanisms are poorly understood. Utilizing neurites generated from murine dorsal root ganglia confined to a semisolid matrix, the pathways involved in the PNI of HNSCC cell lines can be investigated.
