JoVE 비디오를 활용하시려면 도서관을 통한 기관 구독이 필요합니다. 전체 비디오를 보시려면 로그인하거나 무료 트라이얼을 시작하세요.
Chapters
- 00:05Title
- 00:54Administration of Test Substance and Preparation of FITC-Dextran
- 02:42Preparation of the Left Jugular Vein and Injection of FITC-Dextran
- 03:51Positioning the Right Ear for Intravital Fluorescence Microscopy
- 05:24Intravital Fluorescence Microscopy and Thrombus Induction of the Right Ear
- 07:01Venular Thrombus Formation after Single Cannabinoid Treatment and Cyclooxygenase Inhibition
- 08:03Conclusion
The ear model of the hairless SKH1-Hrhr mouse enables intravital fluorescence microscopy of microcirculation and phototoxic thrombus induction without prior surgical preparation in the examined microvascular bed. Therefore, the ear of the hairless mouse is an excellent in vivo model to study the complex interactions during microvascular thrombus formation, thrombus evolution, and thrombolysis.
