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小鼠主动脉夹层损伤：高效<em>体内</em>平滑肌细胞增殖和内皮功能模型
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Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function
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小鼠主动脉夹层损伤：高效<em>体内</em>平滑肌细胞增殖和内皮功能模型

DOI:
10.3791/55201-v

•

06:14 min

•

June 11, 2017

•

, , , ,
1Department of Surgery,Baltimore Veterans Affairs Medical Center, 2Department of Surgery,University of Maryland School of Medicine, 3Department of Physiology,University of Maryland School of Medicine, 4Center for Vascular and Inflammatory Diseases,University of Maryland School of Medicine

Chapters

  • 00:05Title
  • 00:49Murine Aortic Crush Injury and Post-procedure Care
  • 02:34Tissue Procurement
  • 03:54Results: Representative Effects of Crush Injury on Aortic Wall Thickening and Function
  • 05:37Conclusion

Summary

자동 번역

자동 번역

心血管手术后的再狭窄（旁路手术，血管成形术或支架置入术）是降低这些手术的耐久性的重大问题。理想的治疗方法是抑制平滑肌细胞（VSMC）的增殖，同时促进内皮的再生。我们描述了同时评估体内VSMC增殖和内皮功能的模型。

Tags

Murine Aortic Crush InjuryVascular Smooth Muscle Cell ProliferationReendothelializationRestenosisVascular BiologyIn Vivo ModelC57BL/6 MouseAnesthesiaLaparotomyAorta CrushEvans Blue DyeEndothelial Function

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