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Une procédure exhaustive pour évaluer la<em> In Vivo</em> Performance du Cancer nanomédicaments
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JoVE 신문 암 연구학
A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines
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Une procédure exhaustive pour évaluer la<em> In Vivo</em> Performance du Cancer nanomédicaments

DOI:
10.3791/55271-v

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07:59 min

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March 04, 2017

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, , , , ,
1Department of Radiology,Memorial Sloan Kettering Cancer Center, 2Translational and Molecular Imaging Institute,Icahn School of Medicine at Mount Sinai

Chapters

  • 00:05Title
  • 00:56Synthesis of Dual-labeled Liposomal Nanoparticles
  • 03:22In Vivo PET-CT Imaging and Ex Vivo Biodistribution Measurements
  • 06:19Results: Biodistribution of Fluorescent- and Radiolabeled Nanoparticles in Tumor-bearing Mice
  • 07:14Conclusion

Summary

자동 번역

자동 번역

The poor understanding of the in vivo performance of nanomedicines stymies their clinical translation. Procedures to evaluate the in vivo behavior of cancer nanomedicines at systemic, tissue, single-cell, and subcellular levels in tumor-bearing immunocompetent mice are described here. This approach may help researchers to identify promising cancer nanomedicines for clinical translation.

Tags

Cancer NanomedicinesIn Vivo PerformanceTumor-bearing MiceDual-labeling ApproachLiposomesLipophilic Cationic Fluorescent DyePhosphate-buffered SalineDynamic Light ScatteringRadiolabelingZirconium-89 OxalateSize-exclusion HPLCRadiochemical Purity

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