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1Division of Gastroenterology and Liver Disease, University Hospitals, Digestive Health Research Institute,Case Western Reserve University, 2Case Cardiovascular Research Institute, School of Medicine,Case Western Reserve University, 3Department of Medicine, Harrington Discovery Institute, Harrington Heart and Vascular Institute,University Hospitals Case Medical Center, 4Department of Radiology,University Hospitals Case Medical Center, 5Department of Biology – Skeletal Research Center,Case Western Reserve University
Chapters
- 00:05Title
- 01:09Ultrasound-guided Intracardiac Human Mesenchymal Stem Injection
- 03:59hMSC Bioluminescent (BLI) Imaging
- 05:31Results: Representative In Vivo hMSC Visualization
- 06:13Conclusion
Murine studies in models of colonic inflammation have demonstrated that a small percentage (1 - 5%) of mesenchymal stem cells (MSC) injected intravenously or intraperitoneally home to the inflamed colon1,2. This study shows that ultrasound-guided intracardiac injections of MSCs result in increased localization to the intestine.
