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JoVE Journal Neuroscience
Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0
 

Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0

Article DOI: 10.3791/55595-v • 07:41 min • June 5th, 2017
June 5th, 2017 •
1,2,3, 2, 2,4, 1,2,3
1Center for Neuroscience, University of Pittsburgh, 2Department of Physical Medicine & Rehabilitation, University of Pittsburgh, School of Medicine, 3Safar Center for Resuscitation Research, University of Pittsburgh, 4Department of Biological Sciences, Mellon College of Science, Carnegie Mellon University

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요약
Automatic Translation

Fast-scan cyclic voltammetry can monitor in vivo dopamine neurotransmission in the context of drugs, disease, and other experimental manipulations. This work describes the implementation of QNsim1.0, a software to model electrically stimulated dopamine responses according to the quantitative neurobiological model to quantify estimates of dopamine release and reuptake dynamics.

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Keywords: Fast-scan Cyclic Voltammetry Dopamine Neurotransmission QNsim1.0 Electrically Stimulated Kinetics Modeling User-friendly Platform Quantitative Neurobiological Framework Dopamine Response Data Simulation Time Sampling Interval New Project Continue Previous Project
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