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Genetics

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JoVE Journal Genetics
Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
 

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Article DOI: 10.3791/56221-v • 09:04 min • September 21st, 2017
September 21st, 2017 •
*1, *1, 1
1Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University
* These authors contributed equally

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요약
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We report the protocols for the synthesis and purification of Peptide Nucleic Acid (PNA) oligomers incorporating modified residues. The biochemical and biophysical methods for the characterization of the recognition of RNA duplexes by the modified PNAs are described.

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Double-stranded RNAs Single-stranded RNAs Chemically Modified Peptide Nucleic Acids Molecular Recognition RNA Chemical Biology Detection Of RNA Structures Targeting RNA Structures RNA Duplex Structures Gel Electrophoresis Polyacrylamide Gel Voltage Ethidium Bromide
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