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Journal / Neuroscience / Partial Optic Nerve Transection in Rats: A Model…
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JoVE Journal Neuroscience
Partial Optic Nerve Transection in Rats
 

Partial Optic Nerve Transection in Rats: A Model Established with a New Operative Approach to Assess Secondary Degeneration of Retinal Ganglion Cells

Article DOI: 10.3791/56272-v • 13:12 min • October 15th, 2017
October 15th, 2017 •
1, 2, 2, 3, 3, 4, 4, 3
1Aier School of Ophthalmology, Central South University, Changsha, China, 2Institute of Immunology, Tsinghua University School of Medicine, Beijing, China, 3Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, China, 4Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, China

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Automatic Translation

Secondary degeneration of retinal ganglion cells (RGCs) occurs commonly in glaucoma. This study describes an innovative operative approach for partial optic nerve transection. The use of this space-saving operative approach extends the model's application range, and allows exploration of secondary injury mechanisms in RGCs in a new way.

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Keywords: Partial Optic Nerve Transection Secondary Degeneration Retinal Ganglion Cells Glaucoma Novel Surgical Approach Space-saving Technique Optic Nerve Stabilization Primary And Secondary Injury
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